Bond R, McNeil P E, Evans H, Srebernik N
Department of Small Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
Vet Rec. 1995 May 6;136(18):466-71. doi: 10.1136/vr.136.18.466.
Two dogs with metabolic epidermal necrosis had hyperkeratosis of the footpads accompanied by erythematous, erosive and crusting lesions affecting the muzzle, external genitalia, perineum and periocular regions. Histopathological examination of skin biopsies revealed a superficial hydropic dermatitis with marked parakeratosis. Both dogs had high plasma activities of alkaline phosphatase and alanine aminotransferase and high concentrations of glucose, and also a marked hypoaminoacidaemia. Despite these similarities, the cutaneous eruptions were associated with different underlying diseases. One dog had a pancreatic carcinoma which had metastasised widely; the primary tumour and the metastases showed glucagon immunoreactivity on immunocytochemical staining, and the dog's plasma glucagon concentration was markedly greater than that of control dogs. The other dog had diffuse hepatic disease; its plasma glucagon concentration was similar to that of control samples and cirrhosis was identified post mortem. Metabolic epidermal necrosis in dogs is a distinct cutaneous reaction pattern which may be associated with different underlying systemic diseases; however, the pathogenesis of the skin lesions remains unclear.
两只患有代谢性表皮坏死的犬脚垫出现角化过度，同时口鼻部、外生殖器、会阴和眼周区域出现红斑、糜烂和结痂性病变。皮肤活检的组织病理学检查显示为浅表性水疱性皮炎伴显著的角化不全。两只犬的血浆碱性磷酸酶和丙氨酸转氨酶活性均升高，血糖浓度升高，且存在明显的低氨基酸血症。尽管有这些相似之处，但皮肤疹与不同的潜在疾病相关。一只犬患有广泛转移的胰腺癌；免疫细胞化学染色显示原发性肿瘤和转移灶有胰高血糖素免疫反应性，且该犬的血浆胰高血糖素浓度明显高于对照犬。另一只犬患有弥漫性肝病；其血浆胰高血糖素浓度与对照样本相似，死后尸检发现有肝硬化。犬的代谢性表皮坏死是一种独特的皮肤反应模式，可能与不同的潜在全身性疾病相关；然而，皮肤病变的发病机制仍不清楚。
