Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De Feo F, Ciapparelli A, Dell'Osso L, Bombardieri S
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy.
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):225-30.
To examine the possible role of the soluble factor in fibromyalgia (FM) by studying the correlation of cytokine levels with the patients' clinical and psychiatric profile.
Eighty FM patients underwent clinical and psychiatric evaluations, and plasma levels of cytokines (IL-1, IL-6, IL-8, IL-10, TNF-alpha), aspecific markers of inflammation, rheumatoid factor (RF), anti-extractable nuclear antigen (ENA) antibodies, and anti-nuclear factor (FAN) were measured.
Higher levels of IL-10, IL-8 and TNF-alpha were found in FM patients than in controls. Significant correlations between the biochemical parameters and clinical data were found.
The higher levels of cytokines found in FM patients suggest the presence of an inflammatory response system (IRS) and highlight a parallel between the clinical symptoms and biochemical data. They support the hypothesis that cytokines may play a role in the clinical features of fibromyalgia. In addition, the similar cytokine patterns found in FM patients with different psychiatric profiles suggests that IRS impairment may play a specific role in the disease.
通过研究细胞因子水平与患者临床及精神状况的相关性，探讨可溶性因子在纤维肌痛（FM）中的可能作用。
对80例FM患者进行临床和精神评估，并检测细胞因子（IL-1、IL-6、IL-8、IL-10、TNF-α）、炎症非特异性标志物、类风湿因子（RF）、抗可提取核抗原（ENA）抗体及抗核因子（FAN）的血浆水平。
FM患者中IL-10、IL-8和TNF-α水平高于对照组。发现生化参数与临床数据之间存在显著相关性。
FM患者中发现的较高细胞因子水平提示存在炎症反应系统（IRS），并突出了临床症状与生化数据之间的平行关系。它们支持细胞因子可能在纤维肌痛临床特征中起作用的假说。此外，在具有不同精神状况的FM患者中发现的相似细胞因子模式表明IRS损伤可能在该疾病中起特定作用。
