Fink A M, Cauza E, Hassfeld W, Dunky A, Bayer P M, Jurecka W, Steiner A
Department of Dermatology, Wilhelminenspital, Vienna, Austria.
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):305-8.
To determine the levels of vascular endothelial growth factor (VEGF) in patients with active psoriatic arthritis, patients with inactive psoriatic arthritis, and healthy controls. Serum VEGF levels were correlated with clinical and laboratory features in patients with active psoriasis arthritis.
Serum samples from 14 patients with active psoriatic arthritis, 14 patients with inactive psoriatic arthritis, and 9 healthy controls were investigated. VEGF levels in the serum were measured using a sensitive sandwich ELISA.
The mean serum VEGF concentration in patients with active PA was 394.4 pg/ml (394 +/- 171.8), in patients with inactive PA 200.4 pg/ml (200.4 +/- 115.7), and in healthy subjects 214.3 pg/ml (214.3 +/- 162.1). Patients with active psoriasis arthritis had significantly higher levels of VEGF compared to patients with inactive psoriasis arthritis and healthy individuals (p > 0.001). In contrast, VEGF levels were comparable in patients with inactive psoriatic arthritis and controls (p =0.659). Furthermore, in patients with psoriatic arthritis, VEGF levels were positively correlated with ESR, HAQ, PASI and VAS.
VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
测定活动期银屑病关节炎患者、非活动期银屑病关节炎患者及健康对照者血管内皮生长因子（VEGF）水平，并探讨活动期银屑病关节炎患者血清VEGF水平与临床及实验室特征的相关性。
研究对象包括14例活动期银屑病关节炎患者、14例非活动期银屑病关节炎患者和9例健康对照者。采用灵敏的夹心酶联免疫吸附测定法（ELISA）检测血清VEGF水平。
活动期银屑病关节炎患者血清VEGF平均浓度为394.4 pg/ml（394±171.8），非活动期患者为200.4 pg/ml（200.4±115.7），健康对照者为214.3 pg/ml（214.3±162.1）。活动期银屑病关节炎患者的VEGF水平显著高于非活动期患者及健康个体（p>0.001）。相比之下，非活动期银屑病关节炎患者与对照者的VEGF水平相当（p=0.659）。此外，银屑病关节炎患者的VEGF水平与血沉（ESR）、健康评估问卷（HAQ）、银屑病面积和严重程度指数（PASI）及视觉模拟评分（VAS）呈正相关。
VEGF水平可被视为活动期银屑病关节炎的良好指标。
