Ablin Jacob N, Goldstein Zacharinka, Aloush Valerie, Matz Hagit, Elkayam Ori, Caspi Dan, Swartzenberg Shmuel, George Jacob, Wohl Yonit
The Department of Rheumatology, Rheumatology Institute, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
Rheumatol Int. 2009 Jan;29(3):257-62. doi: 10.1007/s00296-008-0676-7. Epub 2008 Aug 15.
Endothelial progenitor cells (EPCs) are a population of bone marrow derived cells which have been attributed with the ability to migrate into areas of tissue ischemia and to posses reparative qualities. EPCs have been shown to be decreased in level and function in various inflammatory disorders. Psoriasis and psoriatic arthritis are associated with an increase in cardiovascular morbidity. The aim of the study was to investigate the number of EPCs among patients suffering from psoriasis and psoriatic arthritis. Patients suffering from active psoriasis and psoriatic arthritis were recruited as well as healthy controls. Disease activity was assessed with the DAS-28, BASDAI and PASI scores. Peripheral blood mononuclear cells were isolated and EPC numbers evaluated by FACS analysis using the CD34/133 and CD34/KDR. No significant difference was found between numbers of EPCs between healthy controls, patients with psoriasis and psoriatic arthritis. A significant correlation was found between levels of VGEF and the BASDAI score. The results of the current study do not support a significant role for EPCs in the pathogenesis of psoriasis and psoriatic arthritis.
内皮祖细胞（EPCs）是一群源自骨髓的细胞，具有迁移至组织缺血区域并具备修复特性的能力。在各种炎症性疾病中，EPCs的水平和功能已被证明会降低。银屑病和银屑病关节炎与心血管疾病发病率的增加有关。本研究的目的是调查银屑病和银屑病关节炎患者中EPCs的数量。招募了患有活动性银屑病和银屑病关节炎的患者以及健康对照。使用DAS-28、BASDAI和PASI评分评估疾病活动度。分离外周血单个核细胞，并通过使用CD34/133和CD34/KDR的流式细胞术分析评估EPC数量。在健康对照、银屑病患者和银屑病关节炎患者的EPC数量之间未发现显著差异。发现VGEF水平与BASDAI评分之间存在显著相关性。本研究结果不支持EPCs在银屑病和银屑病关节炎发病机制中起重要作用。
