Dlin V V, Asratian A A, Reĭzis A R, Malinovskaia V V, Markarian A S
Pediatriia. 1991(7):24-7.
The purpose of the present work was to study the rate of HB viral infection from the standpoint of its pathogenetic importance in children with the nephrotic syndrome (NS). As many as 71 children aged 2 to 15 years with the NS were examined. 23 children with hematuric glomerulonephritic (GN) served as control. HB viral infection markers (HBsAg, anti-HBs, total anti-HBc and IgM anti-HBc) were detected in the blood serum by means of IEA in all the patients. The examinations made it possible to reveal material differences in the distribution of various combinations of VHB markers in children with the NS and hematuric GN. The combination of HBsAg and IgM anti-HBc turned out most characteristic for the NS, pointing to active NB viral infection. In patients with mixed GN, that combination was detectable twice as often. The data obtained attest te a high rate of the association of HB viral infection with GN, particularly with that running its course with the NS. In this case, the rate mentioned was significantly higher than in the population. A definite relationship between the activity of HB viral infection and the gravity of the NS suggests that VHB is implicated in the pathogenesis of GN. This suggestion may be indirectly supported by a far higher rate of HBsAg and IgM anti-HBc demonstration in patients suffering from membranoproliferative GN.
本研究的目的是从乙型肝炎病毒（HB）感染在肾病综合征（NS）患儿发病机制中的重要性角度，研究其感染率。对71例年龄在2至15岁的NS患儿进行了检查。23例血尿性肾小球肾炎（GN）患儿作为对照。采用免疫酶分析法（IEA）检测了所有患者血清中的HB病毒感染标志物（HBsAg、抗-HBs、总抗-HBc和IgM抗-HBc）。检查发现，NS患儿和血尿性GN患儿中HB病毒标志物各种组合的分布存在实质性差异。HBsAg和IgM抗-HBc的组合在NS患儿中最为典型，表明存在活动性HB病毒感染。在混合性GN患者中，该组合的检出率是前者的两倍。所得数据证明HB病毒感染与GN，尤其是与NS病程中的GN关联率很高。在这种情况下，该关联率明显高于总体人群。HB病毒感染的活动性与NS的严重程度之间存在明确关系，这表明HB病毒与GN的发病机制有关。膜增生性GN患者中HBsAg和IgM抗-HBc的检出率高得多，这可能间接支持了这一观点。
