Turrentine Florence E, Henderson William G, Khuri Shukri F, Schifftner Tracy L, Inabnet William B, El-Tamer Mahmoud, Northup C Joseph, Simpson Virginia B, Neumayer Leigh, Hanks John B
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.
J Am Coll Surg. 2007 Jun;204(6):1273-83. doi: 10.1016/j.jamcollsurg.2007.03.014.
Data from the Patient Safety in Surgery Study were used to compare preoperative risk factors, intraoperative variables, and surgical outcomes of adrenalectomy procedures performed in 81 Veterans Affairs (VA) hospitals with those performed in 14 private-sector (PS) hospitals.
This study is a retrospective review of prospectively collected data on all patients undergoing adrenalectomy in the VA and PS for fiscal years 2002 through 2004. Bivariate analysis compared VA and PS preoperative risk factors, intraoperative variables, and 30-day morbidity and mortality. Regression risk-adjustment analysis was used to compare 30-day postoperative morbidity in the VA and PS.
During the 3 years studied, 178 VA patients and 371 PS patients underwent adrenalectomy procedures with a median per site of 2 (range 1-9) and 21 (range 8-70) procedures per VA and PS hospital, respectively. The VA patients had considerably more comorbidities than PS patients. The unadjusted 30-day morbidity rate was significantly higher in VA (16.29%) than PS (6.74%) hospitals (p = 0.0003); after controlling for the higher rate of comorbidities, the adjusted odds ratio for morbidity in the VA versus the PS hospitals was no longer significant (odds ratio = 1.328; 95% CI, 0.488-3.613). Unadjusted mortality rate was VA 2.81%, PS 0.27%, p = 0.0074. The low event rate overall precluded risk adjustment for mortality.
The VA adrenalectomy population has more preoperative risk factors and substantially higher unadjusted 30-day postoperative morbidity and mortality rates than the PS population. After risk adjustment, there is no significant difference in morbidity between the VA and the PS. A larger study population is needed to compare risk-adjusted mortality between the VA and PS.
外科手术患者安全研究中的数据被用于比较在81家退伍军人事务部(VA)医院和14家私立医院(PS)进行的肾上腺切除术的术前风险因素、术中变量及手术结果。
本研究是一项对2002财年至2004财年在VA和PS接受肾上腺切除术的所有患者的前瞻性收集数据的回顾性分析。双变量分析比较了VA和PS的术前风险因素、术中变量以及30天发病率和死亡率。采用回归风险调整分析比较VA和PS的术后30天发病率。
在研究的3年中,178例VA患者和371例PS患者接受了肾上腺切除术,VA医院每个手术点的手术中位数为2例(范围1 - 9例),PS医院每个手术点的手术中位数为21例(范围8 - 70例)。VA患者的合并症比PS患者多得多。VA医院未调整的30天发病率(16.29%)显著高于PS医院(6.74%)(p = 0.0003);在控制了较高的合并症发生率后,VA医院与PS医院发病率的调整优势比不再显著(优势比 = 1.328;95%可信区间,0.488 - 3.613)。未调整的死亡率VA为2.81%,PS为0.27%,p = 0.0074。总体事件发生率较低,无法对死亡率进行风险调整。
与PS人群相比,VA肾上腺切除术人群术前风险因素更多,未调整的术后30天发病率和死亡率显著更高。风险调整后,VA和PS的发病率无显著差异。需要更大的研究人群来比较VA和PS之间风险调整后的死亡率。