Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats.
作者信息
Adjou K T, Allix S, Ouidja M O, Backer S, Couquet C, Cornuejols M-J, Deslys J-P, Brugère H, Brugère-Picoux J, El-Hachimi K H
机构信息
Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
出版信息
J Comp Pathol. 2007 Jul;137(1):78-81. doi: 10.1016/j.jcpa.2007.03.007. Epub 2007 Jun 4.
Immunohistochemical examination demonstrated widespread granular deposits of alpha-synuclein (alphaSN) in the brains of sheep and goats with natural scrapie, especially in the cornu ammonis and subiculum of the hippocampus; this contrasted with the diffuse and non-granular immunolabelling seen in healthy controls. There was non-regular "co-localization" of PrP(Sc) and alphaSN. The findings resembled those reported in Creutzfeldt-Jakob disease and in experimental prion disease in hamsters and mice. The results suggest that perturbation of alphaSN metabolism plays a role in human and animal prion diseases.
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