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癫痫中的精神事件。

Psychiatric events in epilepsy.

作者信息

Cornaggia Cesare Maria, Beghi Massimiliano, Beghi Ettore

机构信息

Clinical Psychiatry, University of Milano Bicocca, V. Cadore 48, 20052 Monza, Milan, Italy.

出版信息

Seizure. 2007 Oct;16(7):586-92. doi: 10.1016/j.seizure.2007.04.006. Epub 2007 Jun 4.

DOI:10.1016/j.seizure.2007.04.006
PMID:17544705
Abstract

Psychiatric events are thought to be more frequent in people with epileptic seizures than in the general population. However, inter-ictal psychiatric events attributable to epilepsy remain controversial. The aim of the present study was to evaluate the occurrence of psychiatric events in a population of fairly unselected patients with epilepsy and in the general population, and the correlation between psychiatric complaints and selected demographic and disease characteristics. The survey was part of a multicentre prospective cohort study of everyday life risks conducted in eight European countries and comparing referral children and adults with epilepsy referred to secondary/tertiary centers to age- and sex-matched non-epileptic controls. Nine hundred and fifty-one patients with epilepsy and 909 controls were studied. Each patient and his/her control received a diary to record any accident or illness, with severity, circumstances, causes, consequences, and (for the cases) the possible relation to a seizure. The follow-up period ranged between 1 and 2 years. Fifty-eight psychiatric events occurred in 25 patients (2.6%) and 88 in 19 controls (2.1%). Housewives (9.3%) and unemployed persons (4.1%) were mostly affected. No correlation was found between psychiatric events, demographic and disease characteristics. Our results suggest that people with epilepsy if unselected are not at higher risk for psychiatric disorders than the general population.

摘要

人们认为癫痫发作患者发生精神事件的频率高于普通人群。然而,由癫痫引起的发作间期精神事件仍存在争议。本研究的目的是评估在一组未经严格筛选的癫痫患者人群以及普通人群中精神事件的发生率,以及精神症状与选定的人口统计学和疾病特征之间的相关性。该调查是一项在八个欧洲国家进行的关于日常生活风险的多中心前瞻性队列研究的一部分,该研究将转诊至二级/三级中心的癫痫儿童和成人与年龄和性别匹配的非癫痫对照进行比较。共研究了951例癫痫患者和909例对照。每位患者及其对照都收到一本日记,用于记录任何事故或疾病,包括严重程度、情况、原因、后果以及(对于病例)与癫痫发作的可能关系。随访期为1至2年。25例患者(2.6%)发生了58起精神事件,19例对照(2.1%)发生了88起。家庭主妇(9.3%)和失业者(4.1%)受影响最大。未发现精神事件与人口统计学和疾病特征之间存在相关性。我们的结果表明,未经筛选的癫痫患者发生精神障碍的风险并不高于普通人群。

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