McKeon Andrew, Josephs Keith A, Klos Kevin J, Hecksel Kathleen, Bower James H, Michael Bostwick J, Eric Ahlskog J
Department of Neurology, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA.
Parkinsonism Relat Disord. 2007 Dec;13(8):516-9. doi: 10.1016/j.parkreldis.2007.04.004. Epub 2007 Jun 4.
Unusual compulsive behaviors (weighing, card and video game playing, fishing, gardening, intense interest in established hobbies, locking and unlocking doors, repetitive dressing and undressing) occurred in relation to dopamine agonist therapy (six patients) and levodopa therapy (one patient) in seven patients with parkinsonism (seven Parkinson's disease, one multiple system atrophy). These behaviors occurred in tandem with pathological gambling, hypersexuality, compulsive eating, compulsive shopping or punding in six of the seven cases. Obsessive thoughts were present in one patient, with no prior history of obsessive-compulsive disorder. The simultaneous occurrence of these phenomenologically distinct behaviors in this group of patients suggests that a broad spectrum of psychopathology may occur in this context and should be monitored for in routine neurological practice.
在7例帕金森综合征患者（7例帕金森病、1例多系统萎缩）中，6例患者在接受多巴胺激动剂治疗时出现了异常强迫行为（称重、玩纸牌和电子游戏、钓鱼、园艺、对既定爱好产生强烈兴趣、反复锁门和开门、反复穿衣和脱衣），1例患者在接受左旋多巴治疗时出现了这些行为。在这7例患者中的6例中，这些行为与病理性赌博、性欲亢进、强迫性进食、强迫性购物或刻板动作同时出现。1例患者出现强迫观念，既往无强迫症病史。这组患者中这些现象学上不同的行为同时出现，表明在这种情况下可能会出现广泛的精神病理学表现，在常规神经科实践中应予以监测。
