Averbeck B B, O'Sullivan S S, Djamshidian A
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415.
Annu Rev Clin Psychol. 2014;10:553-80. doi: 10.1146/annurev-clinpsy-032813-153705. Epub 2013 Dec 2.
Impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence, and risk factors of patients with PD. Results of behavioral studies assessing the neuropsychological profile of patients with PD emphasize that the ICBs, which are behavioral addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis, are discussed, and therapeutic guidelines for the management of ICBs in PD are given.
帕金森病（PD）中的冲动强迫行为（ICBs）是多巴胺替代疗法常见且具有破坏性的副作用。在本综述中，我们描述了帕金森病患者的现象学、患病率和风险因素。评估帕金森病患者神经心理学特征的行为学研究结果强调，作为行为成瘾的冲动强迫行为并非出于享乐动机。相反，诸如无法应对不确定性等其他因素可能引发冲动强迫行为。文中讨论了功能成像研究的新见解，这些见解强化了动机显著性假说，并给出了帕金森病中冲动强迫行为管理的治疗指南。
