Zutter Mary M, Edelson Brian T
Department of Pathology, Cancer Biology and Immunology, Vanderbilt University School of Medicine, C3321A MCN, 1161 21st Avenue S, Nashville, TN 37232, USA.
Immunobiology. 2007;212(4-5):343-53. doi: 10.1016/j.imbio.2006.11.013. Epub 2007 Jan 2.
Our laboratory focuses on the alpha2beta1 integrin, a receptor for a number of matrix and non-matrix ligands, including collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and several viruses. The alpha2beta1 integrin is expressed on numerous different cell types, including epithelial cells, endothelial cells, fibroblasts, and hematopoietic elements, including platelets and specific subsets of leukocytes. Although alpha2beta1 integrin expression is widespread, it is not ubiquitous. Rather, it is expressed in a differentiation-dependent and activation-dependent manner. Interactions between the alpha2beta1 integrin and extracellular matrix ligands have been implicated in important biological processes including inflammation and immunity. Studies from a number of laboratories have demonstrated a role for the alpha2beta1 integrin during the immune response. Our laboratory generated an alpha2beta1 integrin-deficient mouse to define the role of the alpha2beta1 integrin in vivo. Our studies demonstrated that the alpha2-null mice have a profound defect in the innate immune response. We have recently reported the identification of a novel family of ligands for the alpha2beta1 integrin, which include C1q and the collectins. The goal of this article is to review the important role that the interaction between the alpha2beta1 integrin and C1q plays in the innate immune response. The identification of C1q and the collectins as ligands for the alpha2beta1 integrin suggests that the integrin may play important roles in a number of immunological responses.
我们的实验室专注于α2β1整合素，它是多种基质和非基质配体的受体，这些配体包括胶原蛋白、层粘连蛋白、核心蛋白聚糖、E-钙黏蛋白、基质金属蛋白酶-1（MMP-1）、内源性趋化素以及几种病毒。α2β1整合素在多种不同类型的细胞上表达，包括上皮细胞、内皮细胞、成纤维细胞以及造血成分，如血小板和特定的白细胞亚群。尽管α2β1整合素的表达很广泛，但并非无处不在。相反，它是以分化依赖和激活依赖的方式表达的。α2β1整合素与细胞外基质配体之间的相互作用涉及包括炎症和免疫在内的重要生物学过程。许多实验室的研究已经证明了α2β1整合素在免疫反应中的作用。我们的实验室培育了一种α2β1整合素缺陷型小鼠，以确定α2β1整合素在体内的作用。我们的研究表明，α2基因缺失的小鼠在先天免疫反应中存在严重缺陷。我们最近报告了鉴定出α2β1整合素的一个新的配体家族，其中包括C1q和凝集素。本文的目的是综述α2β1整合素与C1q之间的相互作用在先天免疫反应中所起的重要作用。将C1q和凝集素鉴定为α2β1整合素的配体表明，该整合素可能在多种免疫反应中发挥重要作用。
