切除的V(D)J重组副产物会威胁基因组完整性。

Excised V(D)J recombination byproducts threaten genomic integrity.

作者信息

Arnal Suzzette M, Roth David B

机构信息

The Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Pathology, New York University School of Medicine, USA.

出版信息

Trends Immunol. 2007 Jul;28(7):289-92. doi: 10.1016/j.it.2007.05.006. Epub 2007 Jun 4.

DOI:10.1016/j.it.2007.05.006

PMID:17544847

Abstract

Signal joints were long considered to be inert byproducts of V(D)J recombination that protect the genome from illegitimate rearrangements. However, increasing evidence suggests that signal joints are not inert and could pose a threat to genomic stability. A recent study from Nadel and colleagues shows that episomal signal joints readily undergo trans recombination, resulting in their insertion into chromosomal DNA.

摘要

信号接头长期以来被认为是V(D)J重组的惰性副产物，可保护基因组免受非法重排的影响。然而，越来越多的证据表明，信号接头并非惰性，可能对基因组稳定性构成威胁。纳德尔及其同事最近的一项研究表明，游离型信号接头很容易发生转位重组，导致它们插入染色体DNA中。