Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Semin Cancer Biol. 2010 Aug;20(4):254-60. doi: 10.1016/j.semcancer.2010.06.002. Epub 2010 Jul 1.
Vertebrates employ V(D)J recombination to generate diversity for an adaptive immune response. Born of a transposon, V(D)J recombination could conceivably cause more trouble than its worth. However, of the two steps required for transposon mobility (excision and integration) this particular transposon's integration step appears mostly blocked in cells. The employment of a transposon as raw material to develop adaptive immunity was thus a less-risky choice than it might have been … but is it completely risk-free?
脊椎动物利用 V(D)J 重组来产生适应性免疫反应的多样性。V(D)J 重组起源于转座子,它可能带来的麻烦超过了其价值。然而,在转座子移动所必需的两个步骤(切除和整合)中,这种特定转座子的整合步骤在细胞中似乎大多被阻断。因此,将转座子用作开发适应性免疫的原始材料是一个风险较小的选择,而不是像以前那样……但它是否完全没有风险?