Schneider Adrian, Dessimoz Christophe, Gonnet Gaston H
Institute of Computational Science, ETH Zurich, Switzerland.
Bioinformatics. 2007 Aug 15;23(16):2180-2. doi: 10.1093/bioinformatics/btm295. Epub 2007 Jun 1.
Inference of the evolutionary relation between proteins, in particular the identification of orthologs, is a central problem in comparative genomics. Several large-scale efforts with various methodologies and scope tackle this problem, including OMA (the Orthologous MAtrix project).
Based on the results of the OMA project, we introduce here the OMA Browser, a web-based tool allowing the exploration of orthologous relations over 352 complete genomes. Orthologs can be viewed as groups across species, but also at the level of sequence pairs, allowing the distinction among one-to-one, one-to-many and many-to-many orthologs.
推断蛋白质之间的进化关系，特别是直系同源物的鉴定，是比较基因组学中的核心问题。有几项采用不同方法和范围的大规模研究致力于解决这一问题，其中包括OMA（直系同源矩阵项目）。
基于OMA项目的结果，我们在此介绍OMA浏览器，这是一种基于网络的工具，可用于探索352个完整基因组中的直系同源关系。直系同源物可以按物种分组查看，也可以在序列对层面查看，从而区分一对一、一对多和多对多的直系同源物。
