Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA.
Genetics. 2022 Apr 4;220(4). doi: 10.1093/genetics/iyab224.
Saccharomyces cerevisiae is used to provide fundamental understanding of eukaryotic genetics, gene product function, and cellular biological processes. Saccharomyces Genome Database (SGD) has been supporting the yeast research community since 1993, serving as its de facto hub. Over the years, SGD has maintained the genetic nomenclature, chromosome maps, and functional annotation, and developed various tools and methods for analysis and curation of a variety of emerging data types. More recently, SGD and six other model organism focused knowledgebases have come together to create the Alliance of Genome Resources to develop sustainable genome information resources that promote and support the use of various model organisms to understand the genetic and genomic bases of human biology and disease. Here we describe recent activities at SGD, including the latest reference genome annotation update, the development of a curation system for mutant alleles, and new pages addressing homology across model organisms as well as the use of yeast to study human disease.
酿酒酵母被用于提供对真核生物遗传学、基因产物功能和细胞生物学过程的基本理解。酿酒酵母基因组数据库（SGD）自 1993 年以来一直支持着酵母研究界，是其事实上的中心。多年来，SGD 一直维护遗传命名法、染色体图谱和功能注释，并开发了各种用于分析和整理各种新兴数据类型的工具和方法。最近，SGD 和其他六个专注于模式生物的知识库联合起来，创建了基因组资源联盟，以开发可持续的基因组信息资源，促进和支持利用各种模式生物来理解人类生物学和疾病的遗传和基因组基础。在这里，我们描述了 SGD 的最新活动，包括最新的参考基因组注释更新、突变等位基因编目系统的开发，以及新的页面，用于处理模型生物之间的同源性以及利用酵母研究人类疾病的问题。
