Boström Fredrik, Jönsson Linus, Minthon Lennart, Londos Elisabet
Clinical Memory Research Unit, Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden.
Alzheimer Dis Assoc Disord. 2007 Apr-Jun;21(2):150-4. doi: 10.1097/WAD.0b013e318065c4a9.
The primary aim of this study was to compare quality of life (QoL) in patients with Dementia with Lewy Bodies (DLB) and patients with Alzheimer disease (AD). The secondary aim of this study was to investigate determinants of QoL in DLB. Thirty-four patients with DLB at the Neuropsychiatry clinic, University Hospital MAS, Malmö, Sweden, were included in a cross-sectional study. These patients were matched to 34 patients with AD. Two QoL instruments, the EQ-5D instrument and the Quality of Life-Alzheimer disease (QoL-AD) instrument, were applied in this study. Both instruments were administered to both patients and caregivers. Patients with DLB in this study have significantly lower QoL than patients with AD regardless of instrument or whether patient or caregiver-reported QoL was used. Furthermore, this study shows that important determinants of QoL in DLB include Neuropsychiatric Inventory score, independency in instrumental activities of daily living, whether the patient is living with the caregiver and the presence of apathy and delusions.
本研究的主要目的是比较路易体痴呆（DLB）患者与阿尔茨海默病（AD）患者的生活质量（QoL）。本研究的次要目的是调查DLB患者生活质量的决定因素。瑞典马尔默大学医院MAS神经精神病诊所的34例DLB患者纳入了一项横断面研究。这些患者与34例AD患者进行匹配。本研究应用了两种生活质量评估工具，即EQ-5D工具和阿尔茨海默病生活质量（QoL-AD）工具。这两种工具均应用于患者及其照料者。无论使用哪种工具，也无论报告的是患者还是照料者的生活质量，本研究中的DLB患者的生活质量均显著低于AD患者。此外，本研究表明，DLB患者生活质量的重要决定因素包括神经精神科量表评分、日常生活工具性活动的独立性、患者是否与照料者同住以及是否存在淡漠和妄想。
