Swanberg Margaret M
Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Alzheimer Dis Assoc Disord. 2007 Apr-Jun;21(2):164-6. doi: 10.1097/WAD.0b013e318047df5d.
Frontotemporal dementia (FTD) is one of the more common presenile dementias. Unlike Alzheimer disease, there are no approved medications to treat this debilitating condition.
To report the response of memantine on the behavioral manifestations of FTD.
Case series of 3 patients diagnosed with FTD and treated with memantine.
All 3 patients showed an improvement in total Neuropsychiatric Inventory score with specific improvements in the subscale scores of apathy, agitation, and anxiety. Memantine was well tolerated in all patients.
This small case series supports the notion that memantine may have a beneficial effect on the neuropsychiatric symptoms of FTD and should be further studied in a prospective clinical trial.
额颞叶痴呆（FTD）是较常见的早老性痴呆之一。与阿尔茨海默病不同，目前尚无获批用于治疗这种使人衰弱疾病的药物。
报告美金刚对FTD行为表现的疗效。
3例诊断为FTD并接受美金刚治疗的病例系列。
所有3例患者的神经精神科问卷总分均有改善，其中淡漠、激越和焦虑分量表得分有显著改善。所有患者对美金刚耐受性良好。
这个小病例系列支持美金刚可能对FTD的神经精神症状有有益作用这一观点，应在前瞻性临床试验中进一步研究。
