Desjardins A E, Vakoc B J, Bilenca A, Tearney G J, Bouma B E
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Opt Lett. 2007 Jun 1;32(11):1560-2. doi: 10.1364/ol.32.001560.
Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.
本文展示了使用角分辨光学频域成像（OFDI）对光学浑浊介质的散射系数进行非侵入性测量。结果表明，通过对在不同后向散射角度采集的OFDI反射信号进行非相干平均，可以降低散斑噪声，从而能够从单条A线中提取散射系数，其精度比传统OFDI和光学相干断层扫描系统的测量精度高得多。将散斑建模为随机相量和，推导了测量精度与复合角度数量之间的关系。通过组织模型测量对灵敏度分析进行了验证。
