Pereira Rute Cândida, Ferreira Luiz Oscar Cardoso, Diniz Alcides da Silva, Batista Filho Malaquias, Figueirôa José Natal
Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Av. 17 de Agosto 175, Recife, PE 52060-590, Brazil.
Cad Saude Publica. 2007 Jun;23(6):1415-21. doi: 10.1590/s0102-311x2007000600016.
This study aimed to evaluate the efficacy of weekly iron supplementation with or without vitamin A in the treatment of iron deficiency anemia, using an experimental, randomized, non-placebo-controlled design in 1999. 267 schoolchildren 6 to 14 years of age were randomized to two treatment groups: one group (144) received 200mg iron sulfate alone, with 40 mg of elemental iron, while the other (123) received the same iron supplementation dose plus 10,000 IU of vitamin A (both groups for 30 weeks). Final anemia prevalence was reduced from 48.4% to 17.7% (p < 0.001) in the group receiving iron supplementation alone and 58.1% to 14.3% (p < 0.001) in the group receiving iron plus vitamin A. There was no significant difference between the groups at the end of the study according to mean Hb (p = 0.355) and anemia (p = 0.479). There was a significant correction for iron deficiency anemia with weekly iron-alone supplementation, but with no additional advantage of vitamin A. New studies on the synergism between these two micronutrients are recommended.
本研究旨在评估1999年采用实验性、随机、非安慰剂对照设计，每周补充铁剂（无论是否添加维生素A）治疗缺铁性贫血的疗效。267名6至14岁的学童被随机分为两个治疗组：一组（144名）仅接受200毫克硫酸亚铁，含40毫克元素铁，另一组（123名）接受相同剂量的铁补充剂外加10,000国际单位维生素A（两组均治疗30周）。仅接受铁补充剂的组最终贫血患病率从48.4%降至17.7%（p<0.001），接受铁加维生素A的组从58.1%降至14.3%（p<0.001）。根据平均血红蛋白（p=0.355）和贫血情况（p=0.479），研究结束时两组之间无显著差异。每周仅补充铁剂可显著纠正缺铁性贫血，但维生素A并无额外益处。建议对这两种微量营养素之间的协同作用开展新的研究。
