Palma Beatriz Duarte, Tiba Paula Ayako, Machado Ricardo Borges, Tufik Sergio, Suchecki Deborah
Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Braz J Psychiatry. 2007 May;29 Suppl 1:S33-8. doi: 10.1590/s1516-44462007000500007.
To review the literature on the interaction between sleep and the immune system.
A search on Web of Science and Pubmed database including the keywords sleep, sleep deprivation, stress, hypothalamic-pituitary-adrenal axis, immune system, and autoimmune diseases.
On Web of Science, 588 publications were retrieved; 61 references, more significant and closer to our objective, were used, including original articles and review papers.
Sleep deprivation and immune system exert a bidirectional influence on each other. Since sleep deprivation is considered a stressor, inasmuch as it induces elevation of cortisol or corticosterone levels in humans and rodents, respectively, and given the well-known immunosuppressive effect of glucocorticoids, we propose that increased activation of the hypothalamic-pituitary-adrenal axis is a major mediator of the immune alterations observed in patients with insomnia or in sleep deprived subjects.
回顾关于睡眠与免疫系统相互作用的文献。
在科学网（Web of Science）和PubMed数据库中进行检索，关键词包括睡眠、睡眠剥夺、应激、下丘脑-垂体-肾上腺轴、免疫系统和自身免疫性疾病。
在科学网上检索到588篇出版物；使用了61篇更具意义且更接近我们目标的参考文献，包括原创文章和综述论文。
睡眠剥夺与免疫系统相互产生双向影响。由于睡眠剥夺被视为一种应激源，因为它分别导致人类和啮齿动物体内皮质醇或皮质酮水平升高，并且鉴于糖皮质激素众所周知的免疫抑制作用，我们提出下丘脑-垂体-肾上腺轴的激活增加是失眠患者或睡眠剥夺受试者中观察到的免疫改变的主要介导因素。
