Goldman R S, Tandon R, Liberzon I, Goodson J, Greden J F
Schizophrenia Program, University of Michigan Medical Center, Ann Arbor.
Psychopathology. 1991;24(4):247-52. doi: 10.1159/000284721.
To assess the structural stability of positive and negative symptom ratings, we rated 40 schizophrenic inpatients on the Brief Psychiatric Rating Scale (BPRS) and the Scale for the Assessment of Negative Symptoms (SANS) at medication-free baseline and after 4 weeks of neuroleptic treatment. Positive symptom variables consisted of six BPRS items, and the negative symptom variables consisted of the five SANS subscale global scores. On principal components analysis, a three-factor, oblique-rotated solution resulted, with a negative symptom factor, a positive symptom factor, and an unstable behavioral agitation factor. The pre- and posttreatment factor loading patterns were similar. The findings suggest that BPRS-positive symptom items and the SANS measure distinct clinical dimensions and that the construct is stable, as demonstrated by minimal structural change with time.
为评估阳性和阴性症状评分的结构稳定性，我们在无药物基线期及抗精神病药物治疗4周后，使用简明精神病评定量表（BPRS）和阴性症状评定量表（SANS）对40例精神分裂症住院患者进行了评定。阳性症状变量由6个BPRS项目组成，阴性症状变量由5个SANS分量表的总体得分组成。主成分分析得出一个三因素、斜交旋转的结果，包括一个阴性症状因子、一个阳性症状因子和一个不稳定的行为激越因子。治疗前后的因子载荷模式相似。研究结果表明，BPRS阳性症状项目和SANS测量的是不同的临床维度，且该结构是稳定的，这一点从随时间的最小结构变化得到证明。
