由[RuCl(2)Cp*(PPh3)]与镁的混合物催化的原子转移自由基加成（ATRA）和环化（ATRC）反应

Atom-transfer radical addition (ATRA) and cyclization (ATRC) reactions catalyzed by a mixture of [RuCl(2)Cp*(PPh3)] and Magnesium.

作者信息

Thommes Katrin, Içli Burçak, Scopelliti Rosario, Severin Kay

机构信息

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

出版信息

Chemistry. 2007;13(24):6899-907. doi: 10.1002/chem.200700442.

DOI:10.1002/chem.200700442

PMID:17546709

Abstract

A new catalytic procedure for atom-transfer radical addition (ATRA) and cyclization (ATRC) reactions is described. The combination of the ruthenium(III) complex [RuCl(2)Cp*(PPh3)] (Cp*: pentamethylcyclopentadienyl) with magnesium allows these reactions to be performed under mild conditions with high efficiency. In most cases, the catalyst concentrations required are significantly lower than those used in previously reported procedures. It is suggested that magnesium acts as a reducing agent that generates and regenerates the catalytically active ruthenium(II) species. The precatalyst [RuCl(2)Cp*(PPh3)] has been analyzed by X-ray crystallography.

摘要

描述了一种用于原子转移自由基加成（ATRA）和环化（ATRC）反应的新催化方法。钌（III）配合物[RuCl(2)Cp*(PPh3)]（Cp*：五甲基环戊二烯基）与镁的组合使得这些反应能够在温和条件下高效进行。在大多数情况下，所需的催化剂浓度明显低于先前报道方法中使用的浓度。有人认为镁作为一种还原剂，能生成并再生具有催化活性的钌（II）物种。前体催化剂[RuCl(2)Cp*(PPh3)]已通过X射线晶体学进行了分析。