Grek O R, Dolgov A V, Iziumov E G
Farmakol Toksikol. 1976 Jun-Aug;39(4):483-7.
In experiments with mitochondrial membranes and membranes of the endoplasmatic reticulum of the rats' liver the membrane-stabilizing action of a number of unsaturated amines was evaluated. The acetylene compounds studied reduced the extent of the membranes damage following UV-irradiation, treatment with detergents and their incubation in a hypoosmotic medium. Such an action displayed gutimine and sovcaine. Hydrated compounds, analogues of acetylene amines are devoid of the ability to raise the resistance of the cellular organoids membranes to damaging factors
在对大鼠肝脏线粒体膜和内质网膜进行的实验中,评估了多种不饱和胺的膜稳定作用。所研究的乙炔化合物降低了紫外线照射、用去污剂处理以及在低渗介质中孵育后膜的损伤程度。古替明和索夫卡因表现出这种作用。水合化合物,即乙炔胺的类似物,没有提高细胞器膜对损伤因子抵抗力的能力。