Vorhauer-Atlan W, Jacquillat C, Briere J, Chelloul N
Sem Hop. 1975 Apr 14;51(18):1219-25.
The diagnosis of myelofibrosis depends on three fundamental criteria. Myeloid metaplasia of the liver and spleen, absence of Philadelphia chromosome and a variable degree of myelofibrosis. It is thus necessary to have available bone and marrow biopsies to make the diagnosis. The analysis of elementary lesions, together with their grouping, was at the origin of various pathological classifications, including those of Hickling and Jacquillat, Chom and Ripault. The latter, adopted by most authors, distinguishes three histological types, depending on the degree of myelofibrosis and bony sclerosis. They are usually considered as successive stages of the disease.
骨髓纤维化的诊断取决于三个基本标准。肝脾的髓外化生、无费城染色体以及不同程度的骨髓纤维化。因此，进行骨活检和骨髓活检对于做出诊断很有必要。对基本病变及其分组的分析是各种病理分类的起源，包括希克林和雅基拉特、乔姆和里帕尔的分类。后者被大多数作者采用，根据骨髓纤维化和骨质硬化的程度区分三种组织学类型。它们通常被视为疾病的连续阶段。
