t(8;14;18)：两名伯基特淋巴瘤/白血病患者中的一种三向染色体易位。
t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia.
作者信息
Liu Delong, Shimonov Josif, Primanneni Suneeta, Lai Yongrong, Ahmed Tauseef, Seiter Karen
机构信息
Division of Oncology/Hematology, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA.
出版信息
Mol Cancer. 2007 Jun 4;6:35. doi: 10.1186/1476-4598-6-35.
Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.
伯基特淋巴瘤（BL）是一组异质性的高度侵袭性成熟B细胞恶性肿瘤。其特征为恶性细胞的高更新率以及c-myc基因的失调。它通常与t(8;14)易位相关。据报道，t(8;14)（c-myc）和t(14;18)（bcl-2）的双重易位与极差的预后相关。本研究报告了两例伯基特淋巴瘤患者中出现的一种新的t(8;14;18)三重易位。
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