小于胎龄儿母亲孕期的瘦素水平

Maternal leptin across pregnancy in women with small-for-gestational-age infants.

作者信息

Catov Janet M, Patrick Thelma E, Powers Robert W, Ness Roberta B, Harger Gail, Roberts James M

机构信息

Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

出版信息

Am J Obstet Gynecol. 2007 Jun;196(6):558.e1-8. doi: 10.1016/j.ajog.2007.01.032.

DOI:10.1016/j.ajog.2007.01.032

PMID:17547894

Abstract

OBJECTIVE

We hypothesized that women with small-for-gestational-age (SGA) neonates would have lower concentrations of leptin compared to women with appropriately grown infants (AGA).

STUDY DESIGN

This is a nested case-control study of normotensive nulliparous women. Cases (n = 28) delivered SGA < 10 percentile and controls (n = 77) delivered AGA. Maternal plasma leptin concentrations were compared at 18, 28, and 40 weeks' gestation via repeated measures.

RESULTS

Maternal leptin concentrations at 18 weeks were correlated with prepregnancy BMI (r = 0.69, P < .0001) and early pregnancy waist circumference (r = 0.59, P < .0001). After adjustment for maternal body composition, leptin was lower across pregnancy in women with SGA compared to AGA neonates (13.6 vs 15.2 ng/mL at 18 weeks; 13.6 vs 17.3 ng/mL at 28 weeks; 16.6 vs 20.7 ng/mL at 40 weeks; P = .04).

CONCLUSION

Maternal leptin was correlated with maternal adiposity; however, after adjustment for body composition, leptin was lower across pregnancy in women with SGA.

摘要

目的

我们假设，与新生儿体重适合孕周（AGA）的女性相比，孕周小于胎龄（SGA）的女性瘦素浓度更低。

研究设计

这是一项对血压正常的初产妇进行的巢式病例对照研究。病例组（n = 28）分娩的新生儿体重小于第10百分位数，对照组（n = 77）分娩的新生儿体重适合孕周。通过重复测量比较妊娠18、28和40周时孕妇血浆瘦素浓度。

结果

妊娠18周时孕妇瘦素浓度与孕前体重指数相关（r = 0.69，P < .0001），与孕早期腰围相关（r = 0.59，P < .0001）。在对孕妇身体成分进行校正后，与AGA新生儿的母亲相比，SGA新生儿的母亲在整个孕期的瘦素水平较低（18周时为13.6 ng/mL对15.2 ng/mL；28周时为13.6 ng/mL对17.3 ng/mL；40周时为16.6 ng/mL对20.7 ng/mL；P = .04）。