Catov Janet M, Patrick Thelma E, Powers Robert W, Ness Roberta B, Harger Gail, Roberts James M
Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Am J Obstet Gynecol. 2007 Jun;196(6):558.e1-8. doi: 10.1016/j.ajog.2007.01.032.
We hypothesized that women with small-for-gestational-age (SGA) neonates would have lower concentrations of leptin compared to women with appropriately grown infants (AGA).
This is a nested case-control study of normotensive nulliparous women. Cases (n = 28) delivered SGA < 10 percentile and controls (n = 77) delivered AGA. Maternal plasma leptin concentrations were compared at 18, 28, and 40 weeks' gestation via repeated measures.
Maternal leptin concentrations at 18 weeks were correlated with prepregnancy BMI (r = 0.69, P < .0001) and early pregnancy waist circumference (r = 0.59, P < .0001). After adjustment for maternal body composition, leptin was lower across pregnancy in women with SGA compared to AGA neonates (13.6 vs 15.2 ng/mL at 18 weeks; 13.6 vs 17.3 ng/mL at 28 weeks; 16.6 vs 20.7 ng/mL at 40 weeks; P = .04).
Maternal leptin was correlated with maternal adiposity; however, after adjustment for body composition, leptin was lower across pregnancy in women with SGA.
我们假设，与新生儿体重适合孕周（AGA）的女性相比，孕周小于胎龄（SGA）的女性瘦素浓度更低。
这是一项对血压正常的初产妇进行的巢式病例对照研究。病例组（n = 28）分娩的新生儿体重小于第10百分位数，对照组（n = 77）分娩的新生儿体重适合孕周。通过重复测量比较妊娠18、28和40周时孕妇血浆瘦素浓度。
妊娠18周时孕妇瘦素浓度与孕前体重指数相关（r = 0.69，P < .0001），与孕早期腰围相关（r = 0.59，P < .0001）。在对孕妇身体成分进行校正后，与AGA新生儿的母亲相比，SGA新生儿的母亲在整个孕期的瘦素水平较低（18周时为13.6 ng/mL对15.2 ng/mL；28周时为13.6 ng/mL对17.3 ng/mL；40周时为16.6 ng/mL对20.7 ng/mL；P = .04）。
孕妇瘦素与孕妇肥胖相关；然而，在对身体成分进行校正后，SGA孕妇在整个孕期的瘦素水平较低。
