母胎血清瘦素水平及其与母胎变量和分娩的关联：一项横断面研究。
Maternal and fetal serum leptin levels and their association with maternal and fetal variables and labor: A cross-sectional study.
作者信息
Obeidat Rawan A, Abdo Nour, Sakee Baraa, Alghazo Shahed, Jbarah Omar F, Hazaimeh Ethar A, Albeitawi Soha
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Department of Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Ann Med Surg (Lond). 2021 Nov 14;72:103050. doi: 10.1016/j.amsu.2021.103050. eCollection 2021 Dec.
BACKGROUND
Leptin is a polypeptide hormone that may be implicated in the pathogenesis of various disorders during pregnancy. We sought to determine serum leptin levels among pregnant women and their fetuses and to investigate their association with fetal and maternal variables.
METHOD
452 pregnant women who attended to labor ward between January 2020 and August 2020 were included in the study. Serum leptin concentrations were measured using enzyme-linked immunosorbent assay method. Mann-Whitney test and Spearman's correlation test were used for statistical analysis. A multivariate linear regression analysis was then performed. Significance level was considered at alpha <0.05.
RESULTS
The median maternal and fetal serum leptin levels were 6.42 [4.16-8.51] ng/mL and 2.9 [1.03-5.36] ng/mL respectively. There was no significant correlation between maternal and fetal serum leptin levels ( = 0.064). Maternal serum leptin levels correlated positively with maternal body mass index (BMI) ( = 0.117, = 0.005). Besides, maternal serum leptin levels were significantly higher in nulliparous women (7.57 [4.45-9.30] ng/mL vs. 6.22 [4.02-8.30] ng/mL, = 0.037) and in women who were in active labor (6.83 [4.39-8.92] ng/mL vs. 6.25 [4.04-8.30] ng/mL, = 0.047). Fetal serum leptin levels were significantly higher in large for gestational age (LGA) fetuses (4.81 [2.13-7.22] ng/mL vs. 2.80 [0.96-5.16] ng/mL, = 0.003) and in fetuses with preterm premature ruptures of membranes (PPROM) (5.23 [2.42-8.07] ng/mL vs. 2.86 [1.00-5.23] ng/mL, = 0.021).
CONCLUSION
Maternal serum leptin levels were influenced by maternal BMI, parity and labor. Fetal serum leptin levels were higher among LGA fetuses and in fetuses with PPROM.
背景
瘦素是一种多肽激素，可能与孕期各种疾病的发病机制有关。我们试图测定孕妇及其胎儿的血清瘦素水平，并研究它们与胎儿和母亲变量之间的关联。
方法
纳入2020年1月至2020年8月在产房就诊的452名孕妇。采用酶联免疫吸附测定法测量血清瘦素浓度。采用曼-惠特尼检验和斯皮尔曼相关性检验进行统计分析。然后进行多元线性回归分析。显著性水平设定为α<0.05。
结果
母亲和胎儿血清瘦素水平的中位数分别为6.42[4.16 - 8.51]ng/mL和2.9[1.03 - 5.36]ng/mL。母亲和胎儿血清瘦素水平之间无显著相关性（r = 0.064）。母亲血清瘦素水平与母亲体重指数（BMI）呈正相关（r = 0.117，P = 0.005）。此外，初产妇的母亲血清瘦素水平显著更高（7.57[4.45 - 9.30]ng/mL对6.22[4.02 - 8.30]ng/mL，P = 0.037），活跃期分娩的妇女也是如此（6.83[4.39 - 8.92]ng/mL对6.25[4.04 - 8.30]ng/mL，P = 0.047）。大于胎龄（LGA）胎儿的胎儿血清瘦素水平显著更高（4.81[2.13 - 7.22]ng/mL对2.80[0.96 - 5.16]ng/mL，P = 0.003），胎膜早破（PPROM）胎儿的胎儿血清瘦素水平也显著更高（5.23[2.42 - 8.07]ng/mL对2.86[1.00 - 5.23]ng/mL，P = 0.021）。
结论
母亲血清瘦素水平受母亲BMI、产次和分娩的影响。LGA胎儿和PPROM胎儿的胎儿血清瘦素水平较高。
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