Shoenfeld Y, Mozes E
Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
Rheumatol Int. 1991;11(3):91-3. doi: 10.1007/BF00304494.
Systemic lupus erythematosus (SLE) is regarded as a classical autoimmune disease. Despite this belief, no one has been able to induce the disease in naive animals, neither with DNA nor with anti-DNA antibodies. We report on the induction of SLE in BALB/c mice following immunization with a pathogenic anti-DNA idiotype (16/6 Id) or its anti-Id. We also report on a specific treatment with T suppressor cells specific for the 16/6 Id. The induction of SLE in naive mice with a pathogenic anti-DNA Id suggests an additional mechanism for the diversity of manifestations in this disease.
系统性红斑狼疮（SLE）被视为一种典型的自身免疫性疾病。尽管有这种认识，但没有人能够在未接触过抗原的动物中诱发该疾病，无论是使用DNA还是抗DNA抗体。我们报告了在用致病性抗DNA独特型（16/6 Id）或其抗独特型免疫BALB/c小鼠后诱导出SLE的情况。我们还报告了用针对16/6 Id的特异性抑制性T细胞进行的特异性治疗。用致病性抗DNA独特型在未接触过抗原的小鼠中诱导出SLE，提示了该疾病表现多样性的一种额外机制。
