Dowidar N, Kolmos H J, Lyon H, Matzen P
Dept. of Medical and Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark.
Scand J Gastroenterol. 1991 Nov;26(11):1137-44. doi: 10.3109/00365529108998605.
The main problem encountered with the use of biliary endoprostheses is their tendency to clog, which necessitates their exchange. We studied this problem by performing light and electron microscopy and bacterial cultures on both unused and clinically used endoprostheses. These examinations showed several basic defects in their manufacture, such as irregular inner surfaces and badly constructed side holes. The deposit that ultimately led to their occlusion was found mainly to be concentrated around the side holes. Minimizing the amount of material, bacteria, and plant fibres adhering to the endoprosthesis is the desired goal and may be achieved by improving their manufacture and design.
使用胆道内支架遇到的主要问题是其堵塞倾向，这就需要对其进行更换。我们通过对未使用过的和临床使用过的内支架进行光学显微镜、电子显微镜检查及细菌培养来研究这一问题。这些检查显示出其制造过程中的几个基本缺陷，比如内表面不规则以及侧孔结构不佳。最终导致其堵塞的沉积物主要集中在侧孔周围。尽量减少附着在内支架上的物质、细菌和植物纤维的量是我们期望达到的目标，这或许可以通过改进其制造工艺和设计来实现。
