Mowry Ellen M, Woo John H, Ances Beau M
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Nat Clin Pract Neurol. 2007 Jun;3(6):341-8. doi: 10.1038/ncpneuro0519.
Baló's concentric sclerosis (BCS) has long been considered to be a variant of multiple sclerosis. Although BCS was initially described over 100 years ago, relatively few antemortem cases have been identified, and the exact pathogenesis remains unknown. Inflammatory protective ischemic preconditioning has recently been suggested as a mechanism by which the typical concentric rings of the BCS lesion are formed. Advanced neuroimaging can provide important in vivo markers of disease progression that can assist in the diagnosis and management of patients with BCS. In this Review, we discuss evidence from longitudinal neuroimaging studies that supports the role of ischemic preconditioning in BCS.
巴洛同心性硬化（BCS）长期以来一直被认为是多发性硬化的一种变体。尽管BCS早在100多年前就被首次描述，但生前确诊的病例相对较少，确切的发病机制仍然未知。近来有人提出，炎症保护性缺血预处理是BCS病变典型同心环形成的一种机制。先进的神经影像学检查能够提供重要的疾病进展活体标记物，有助于BCS患者的诊断和管理。在本综述中，我们讨论了纵向神经影像学研究的证据，这些证据支持缺血预处理在BCS中的作用。
