Ogorodova L M, Freidin M B, Sazonov A E, Fedorova O S, Gerbek I E, Cherevko N A, Lebedeva N Yu
Siberian State Medical University, Tomsk, Russia.
Parasitol Res. 2007 Sep;101(4):1165-8. doi: 10.1007/s00436-007-0588-6. Epub 2007 Jun 5.
The study was aimed to estimate the relationship between the prevalence of allergic disease and helminth invasion by the trematode Opisthorchis felineus in rural and urban populations of Tomsk Oblast (West Siberia, Russia). Two hundred and one people from Kargasok village of Tomsk Oblast and 196 from the city of Tomsk were screened for the presence of atopy and O. felineus invasion. Opisthorchosis was found in 66 participants (32.8%) from Kargasok and in 22 people (11.2%) from Tomsk. Atopic diseases were more common in the urban population than in the rural: 52.8 and 31.4%, respectively. Positive skin-prick tests were significantly higher in the urban population than in rural people: 83.2 vs 24.4%, respectively. It was found that in the city, the presence of antibodies to O. felineus negatively correlates with the atopic sensitization by skin-prick tests. However, in the village, opisthorchosis was positively associated with atopic diseases. The data obtained confirm the negative association of rural lifestyle and atopic diseases prevalence and indicate that O. felineus invasion might be a modifying factor of this relationship in Tomsk Oblast.
该研究旨在评估俄罗斯西西伯利亚托木斯克州城乡居民中过敏性疾病患病率与猫后睾吸虫这种蠕虫感染之间的关系。对托木斯克州卡尔加索克村的201人和托木斯克市的196人进行了特应性和猫后睾吸虫感染筛查。在卡尔加索克村的66名参与者（32.8%）和托木斯克市的22人（11.2%）中发现了后睾吸虫病。特应性疾病在城市人口中比农村人口中更常见，分别为52.8%和31.4%。城市人口中阳性皮肤点刺试验的比例显著高于农村人口，分别为83.2%和24.4%。研究发现，在城市中，针对猫后睾吸虫的抗体的存在与皮肤点刺试验的特应性致敏呈负相关。然而，在农村，后睾吸虫病与特应性疾病呈正相关。获得的数据证实了农村生活方式与特应性疾病患病率之间的负相关，并表明猫后睾吸虫感染可能是托木斯克州这种关系的一个调节因素。
