碳-11修饰米非司酮类似物库的合成。
Synthesis of C-11 modified mifepristone analog libraries.
作者信息
Hamilton Gregory L, Backes Bradley J
机构信息
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA.
出版信息
Mol Divers. 2007 May;11(2):107-11. doi: 10.1007/s11030-007-9058-4. Epub 2007 Jun 6.
Substitution of the C-11 aniline of mifepristone can provide compounds with altered pharmacokinetic and pharmacodynamic (PK/PD) profiles that may find use for new indications. The development of new steroid intermediates and specialized library synthesis methods were required to enable the efficient preparation of structurally complex C-11 modified mifepristone analogs.
米非司酮C-11位苯胺的取代可提供具有改变的药代动力学和药效学（PK/PD）特征的化合物，这些化合物可能会用于新的适应症。需要开发新的甾体中间体和专门的库合成方法，以有效地制备结构复杂的C-11修饰的米非司酮类似物。
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