Xu Liping, Yu Guoning, Zhang Erlin, Pan Feng, Yang Ke
Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
J Biomed Mater Res A. 2007 Dec 1;83(3):703-11. doi: 10.1002/jbm.a.31273.
Magnesium alloy has been implanted in rats to investigate the in vivo degradation behavior of magnesium for bone implant application. After 9 weeks postoperation, 100% implants were fixed and no inflammation was observed. Histological analysis showed new bone was formed around magnesium implant and no difference was found in the histological microstructure of the new bone and the cortical bone. A degradation or reaction layer, which was mainly composed of Ca, P, O, and Mg, was formed on the surface of magnesium alloy implants. High Ca content in the degradation layer displayed that magnesium could promote the deposition of Ca. Residual area calculation has showed that 10-17% magnesium alloy implant has been degraded in vivo. Compared with that of the controlled rats, no increase in serum magnesium and no disorder of kidney were observed after 15 weeks postoperation. After 18 weeks postoperation, 100% magnesium implants were fixed and no inflammation was observed. About 54% magnesium implant has degraded in vivo. Element analysis showed that Zn and Mn in Mg-Mn-Zn alloy distributed homogeneously in the residual magnesium implant, the degradation layer, and the surrounding bone tissue after 18 weeks implantation, indicating that Zn and Mn elements were easily absorbed by bioenvironment.
已将镁合金植入大鼠体内，以研究镁在骨植入应用中的体内降解行为。术后9周，100%的植入物固定，未观察到炎症。组织学分析表明，镁植入物周围形成了新骨，新骨与皮质骨的组织微观结构无差异。在镁合金植入物表面形成了一层主要由钙、磷、氧和镁组成的降解或反应层。降解层中高钙含量表明镁可促进钙的沉积。残余面积计算表明，10-17%的镁合金植入物在体内已降解。与对照大鼠相比，术后15周血清镁未升高，肾脏未出现紊乱。术后18周，100%的镁植入物固定，未观察到炎症。约54%的镁植入物在体内已降解。元素分析表明，植入18周后，Mg-Mn-Zn合金中的锌和锰在残余镁植入物、降解层和周围骨组织中分布均匀，表明锌和锰元素易于被生物环境吸收。
