Gugger M
Pneumologische Abteilung, Medizinische Universitätsklinik, Inselspital, Bern.
Ther Umsch. 1991 Nov;48(11):736-40.
Abnormal physical exhaustion and fatigue are often simply regarded as a natural consequence of pulmonary diseases. Apart from factors not specifically related to pulmonary diseases (e.g. consequences of infections or malignant diseases of the lungs), increased work of breathing due to impaired lung/thoracic cage mechanics, the effects of chronic hypoxia and hypercapnia, the consequences of disturbed sleep and psychosocial factors are mainly responsible for the impaired physical fitness and the fatigue in association with lung diseases. A careful case history including psychosocial aspects and a thorough physical examination are essential for an efficient diagnostic evaluation. Tests of pulmonary function not only in the awake patient at rest, but also during sleep or adequate physical exercise can reveal the causes of impaired physical performance and fatigue related to lung diseases.
异常的身体疲惫和乏力常常被简单地视为肺部疾病的自然结果。除了与肺部疾病无特定关联的因素（如肺部感染或恶性疾病的后果）外，肺/胸廓力学受损导致的呼吸功增加、慢性缺氧和高碳酸血症的影响、睡眠障碍的后果以及社会心理因素，主要是造成与肺部疾病相关的体能下降和疲劳的原因。包含社会心理方面的详细病史和全面的体格检查对于有效的诊断评估至关重要。不仅要对清醒、静息状态的患者进行肺功能测试，在睡眠期间或适当的体育锻炼时进行测试，也能够揭示与肺部疾病相关的身体机能受损和疲劳的原因。
