白细胞介素-27通过对信号转导和转录激活因子1的不同作用来控制诱导性调节性T细胞和辅助性T细胞17的发育。
IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1.
作者信息
Neufert Clemens, Becker Christoph, Wirtz Stefan, Fantini Massimo C, Weigmann Benno, Galle Peter R, Neurath Markus F
机构信息
Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany.
出版信息
Eur J Immunol. 2007 Jul;37(7):1809-16. doi: 10.1002/eji.200636896.
IL-27 is an IL-12-related cytokine frequently present at sites of inflammation that can promote both anti- and pro-inflammatory immune responses. Here, we have analyzed the mechanisms how IL-27 may drive such divergent immune responses. While IL-27 suppressed the development of proinflammatory Th17 cells, a novel role for this cytokine in inhibiting the development of anti-inflammatory, inducible regulatory T cells (iTreg) was identified. In fact, IL-27 suppressed the development of adaptive, TGF-beta-induced Forkhead box transcription factor p3-positive (Foxp3(+)) Treg. Whereas the blockade of Th17 development was dependent on the transcription factor STAT1, the suppression of iTreg development was STAT1 independent, suggesting that IL-27 utilizes different signaling pathways to shape T cell-driven immune responses. Our data thus demonstrate that IL-27 controls the development of Th17 and iTreg cells via differential effects on STAT1.
白细胞介素-27（IL-27）是一种与白细胞介素-12相关的细胞因子，经常出现在炎症部位，可促进抗炎和促炎免疫反应。在此，我们分析了IL-27驱动这种不同免疫反应的机制。虽然IL-27抑制促炎性辅助性T细胞17（Th17）的发育，但该细胞因子在抑制抗炎性诱导调节性T细胞（iTreg）发育方面的新作用被发现。事实上，IL-27抑制适应性转化生长因子-β（TGF-β）诱导的叉头框转录因子p3阳性（Foxp3(+)）调节性T细胞的发育。虽然Th17发育的阻断依赖于转录因子信号转导和转录激活因子1（STAT1），但iTreg发育的抑制不依赖于STAT1，这表明IL-27利用不同的信号通路来塑造T细胞驱动的免疫反应。因此，我们的数据表明，IL-27通过对STAT1的不同作用来控制Th17和iTreg细胞的发育。
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