Vernet G, Oules O, Poinas-Caillaud H, Raffaillat-Bonhomme D, Monange P, Lavarenne J
Service de Pneumologie, Centre Hospitalier Emile Roux, Le Puy-en-Velay.
Therapie. 1991 Sep-Oct;46(5):367-8.
Metapramine (Timaxel) is a tricyclic antidepressant drug devoid of anticholinergic properties. As other psychotropic drugs, it may induce hyperthermia and several case-reports have been published. Agranulocytosis is an exceptional side-effect of this drug. Even if several cases have been reported to Pharmacovigilance structures in France, as far as we know there is no publication of this unwanted effect. The authors reported the case of an old woman who has presented two episodes of fever and asthenia. Blood formula was both times characterized by agranulocytosis without anemia nor thrombocytopenia. The accidental rechallenge of metapramine permitted to conclude to a causal relationship between these hematological events and metapramine intake.
甲丙氨酯（替马西泮）是一种无抗胆碱能特性的三环类抗抑郁药。与其他精神药物一样，它可能会诱发高热，并且已经发表了几例病例报告。粒细胞缺乏症是这种药物罕见的副作用。尽管在法国有几例病例已上报给药物警戒机构，但据我们所知，尚未有关于这种不良反应的出版物。作者报告了一位老年女性出现两次发热和乏力发作的病例。两次血常规检查均显示为粒细胞缺乏症，无贫血和血小板减少。再次意外服用甲丙氨酯后，可以确定这些血液学事件与服用甲丙氨酯之间存在因果关系。
