Le Jeunne C, Plaisant O, Henslik V, Hugues F C
Service de Médecine Interne II, Hôpital Laennec, Paris.
Ann Med Interne (Paris). 1988;139(1):29-30.
Because of two hyperthermias, due to metapramine a french antidepressives of the tricyclic family, international literature concerning drug fever induced by psychotropics was reviewed. This study stresses the fact that apart from neuroleptics which are frequently involved in that type of accident, other psychotropics are very rarely responsible of hyperthermia. One hundred and five cases published since 1970 and sufficiently well documented to be analysed according to Dangoumeau's french method of imputation of side effects of drugs, were reviewed. Among these cases, one hundred (95%) corresponded to malignant syndrome of neuroleptics, 89 concerned neuroleptics alone, and 11, neuroleptics associated with other psychotropics. Regarding the different mechanisms which can explain drug fever as described by Lipsky, it seems that concerning psychotropics two types may be retained: Fever due to central dysregulation directly induced by drugs, and mainly, immunoallergic fever, the most frequently seen as described in our two cases.
由于三环类抗抑郁药——法国的一种名为美他帕明的抗抑郁药导致了两次体温过高，因此对国际上有关精神药物引起药物热的文献进行了综述。这项研究强调了这样一个事实，即除了经常引发这类意外的抗精神病药物外，其他精神药物很少导致体温过高。对1970年以来发表的105例病例进行了综述，这些病例记录充分，可根据丹古莫的法国药物副作用归因方法进行分析。在这些病例中，100例（95%）符合抗精神病药物的恶性综合征，其中89例仅涉及抗精神病药物，11例涉及抗精神病药物与其他精神药物联用。关于利普斯基所描述的可解释药物热的不同机制，似乎对于精神药物而言，可归为两类：药物直接引起的中枢调节紊乱导致的发热，主要是免疫过敏性发热，如我们的两个病例中最常见的那样。
