用于杂原子取代的杂芳基氯的铃木-宫浦偶联反应的新型催化剂。
New catalysts for Suzuki-Miyaura coupling reactions of heteroatom-substituted heteroaryl chlorides.
作者信息
Guram Anil S, Wang Xiang, Bunel Emilio E, Faul Margaret M, Larsen Robert D, Martinelli Michael J
机构信息
Chemistry Research and Discovery, Amgen Inc., Thousand Oaks, California 91320-1799, USA.
出版信息
J Org Chem. 2007 Jul 6;72(14):5104-12. doi: 10.1021/jo070341w. Epub 2007 Jun 6.
The new air-stable PdCl2[PR2(Ph-R')]2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88-99%) and high catalyst turnover numbers (up to 10,000 TON).
新型空气稳定的二氯二[PR₂(Ph-R')]钯配合物可由市售试剂轻松制备，在各种杂原子取代的杂芳基氯化物与多种芳基/杂芳基硼酸的铃木-宫浦偶联反应中表现出独特的催化效率。由这些新型配合物催化的偶联反应具有高产物收率（88-99%）和高催化剂周转数（高达10,000 TON）。
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