用于杂芳基氯的通用高效铃木-宫浦交叉偶联反应的新型空气稳定催化剂。
New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.
作者信息
Guram Anil S, King Anthony O, Allen John G, Wang Xianghong, Schenkel Laurie B, Chan Johann, Bunel Emilio E, Faul Margaret M, Larsen Robert D, Martinelli Michael J, Reider Paul J
机构信息
Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA.
出版信息
Org Lett. 2006 Apr 27;8(9):1787-9. doi: 10.1021/ol060268g.
[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10,000 TON) are observed.
[反应：见正文] 新型空气稳定的PdCl₂{P(t)Bu₂(p-R-Ph)}₂（R = H、NMe₂、CF₃）配合物是用于芳基卤化物（包括五元杂芳基卤化物和杂原子取代的六元杂芳基氯化物）与多种芳基硼酸的铃木-宫浦交叉偶联反应的简单、通用且高效的催化剂。观察到高的产物收率（分离收率89 - 99%）和周转数（10,000 TON）。
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