Tavora Fabio, Rassaei Negar, Shilo Konstantin, Foss Robert D, Galvin Jeffrey R, Travis William D, Franks Teri J
Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306, USA.
Arch Pathol Lab Med. 2007 Jun;131(6):970-3. doi: 10.5858/2007-131-970-OPPGAC.
Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes. Distant metastases are rare and their occurrence typically indicates an unfavorable outcome. We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis. The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar. The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation. This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.
腺泡细胞腺癌是一种恶性唾液腺肿瘤，其淋巴管扩散至区域淋巴结的发生率相对较低。远处转移罕见，其发生通常预示着不良预后。我们遇到了一例不寻常的腺泡细胞腺癌，最初表现为肺部病变，而原发性腮腺癌尽管经过广泛的临床评估，但在初次诊断后1年才显现出来。腮腺和肺部肿瘤的组织学、免疫组化及超微结构特征相似。该肿瘤表现出侵袭性，在初次发病后2年内导致患者死亡。这种表现很独特，表明唾液腺型周围肺部肿瘤很可能是转移性的，在确定其原发部位时需要进行仔细的临床评估。
