Bartholomeeusen Stefaan, Vandenbroucke Jan, Truyers Carla, Buntinx Frank
Department of General Practice, Katholieke Universiteit Leuven, Belgium.
Br J Gen Pract. 2007 Jun;57(539):497-9.
This study examined time trends in the incidence of peptic ulcers and oesophagitis, and the prescription of acid-inhibiting drugs in the period 1994-2003. Data were retrieved from records in general practices in Flanders, Belgium. The incidence of duodenal ulcers decreased by two-thirds and the incidence of gastric ulcers halved, the incidence of oesophagitis initially increased and decreased slowly later on. In 10 years the proportion of patients taking proton-pump inhibitors rose sixfold while the proportion taking H(2) antagonists remained stable.
本研究调查了1994年至2003年期间消化性溃疡和食管炎的发病率以及抑酸药物的处方情况。数据取自比利时弗拉芒地区全科医疗记录。十二指肠溃疡的发病率下降了三分之二，胃溃疡的发病率减半，食管炎的发病率起初上升，随后缓慢下降。在10年时间里，服用质子泵抑制剂的患者比例增长了6倍，而服用H2拮抗剂的患者比例保持稳定。
