青少年特发性脊柱侧弯女孩循环瘦素水平与人体测量学参数之间的关联

[Association between circulating leptin level and anthropometric parameters in girls with adolescent idiopathic scoliosis].

作者信息

Sun Xu, Qiu Yong, Qiu Xu-Sheng, Zhu Ze-Zhang, Zhu Feng, Xia Cai-Wei

机构信息

Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2007 Mar 6;87(9):594-8.

PMID:17550726

Abstract

OBJECTIVE

To investigate the correlation between the circulating leptin level and the anthropometric parameters and parameters related to pubertal growth, and to explore the role of leptin in the abnormal growth pattern in girls with adolescent idiopathic scoliosis (AIS).

METHODS

One hundred and twenty AIS girls selected randomly from the out-patient and in-patient departments, divided into 2 groups: Group A1 (n = 73, aged 10 - 13) and Group A2 (n = 47, aged 14 - 17), and 80 14 - 17 year-old healthy girl students receiving physical examination underwent measurement of body height and weight. Body mass index (BMI) was calculated. Peripheral fasting blood samples were collected to detect the level of leptin. The anthropometric data, pubertal status, and circulating leptin level were compared between the AIS girls and the controls. The relationships between leptin and age, menstrual status, body weight, height, BMI and Risser sign were analyzed in the AIS girls.

RESULTS

Eighty-eight AIS girls (73%) and 14 healthy girls (18%) had a BMI score less than 18.0. The mean leptin level of Group A1 was 6.2 microg/L, significantly lower than of Group A2 (8.6 microg/L, P = 0.024). Compared with the healthy controls, the AIS girls had significantly greater corrected height (162.7 cm vs. 160.2 cm, P = 0.026), lower weight (44.3 kg vs. 53.6 kg, P = 0.01), lower BMI (17.5 kg/m(2) vs. 20.9 kg/m(2), P = 0.01), and lower circulating leptin (8.6 microg/L vs. 14.9 microg/L), even after the adjustment for age and menstrual status. An inverse correlation was observed between the leptin level and the age at menarche (AIS, r = -0.428, P < 0.001; controls, r = -0.280, P = 0.013). Whereas, positive correlations were found between leptin and age, menstrual status, body weight, height, BMI, and Risser sign (r = 0.234 - 0.506, P = 0.01 - < 0.001).

CONCLUSION

AIS girls have markedly decreased circulating leptin level. Circulating leptin level is associated with body weight, BMI, and other growth parameters, suggesting that leptin may play an important role in the lower body mass in AIS girls.

摘要

目的

探讨循环瘦素水平与人体测量参数及青春期生长相关参数之间的相关性，并探讨瘦素在青少年特发性脊柱侧凸（AIS）女孩异常生长模式中的作用。

方法

从门诊和住院部随机选取120例AIS女孩，分为2组：A1组（n = 73，年龄10 - 13岁）和A2组（n = 47，年龄14 - 17岁），并对80名接受体检的14 - 17岁健康女学生进行身高和体重测量。计算体重指数（BMI）。采集外周空腹血样检测瘦素水平。比较AIS女孩与对照组的人体测量数据、青春期状态和循环瘦素水平。分析AIS女孩中瘦素与年龄、月经状态（月经初潮年龄、月经情况）、体重、身高、BMI和Risser征之间的关系。

结果

88例AIS女孩（73%）和14例健康女孩（18%）的BMI评分低于18.0。A1组的平均瘦素水平为6.2μg/L，显著低于A2组（8.6μg/L，P = 0.024）。与健康对照组相比，即使在调整年龄和月经状态后，AIS女孩的矫正身高明显更高（162.7 cm对16零2 cm，P = 0.026），体重更低（44.3 kg对53.6 kg，P = 0.01），BMI更低（17.5 kg/m²对20.9 kg/m²，P = 0.01），循环瘦素水平更低（8.6μg/L对14.9μg/L）。在瘦素水平与月经初潮年龄之间观察到负相关（AIS组，r = -0.428，P < 0.001；对照组，r = -0.280，P = 0.013）。然而，发现瘦素与年龄、月经状态、体重、身高、BMI和Risser征之间存在正相关（r = 0.234 - 0.506，P = 0.01 - < 0.001）。