异基因造血干细胞移植（HSCT）长期存活者中单纯输血后铁过载的磁共振成像定量分析及肝脏后果
Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long term survivors after allogeneic hematopoietic stem cell transplantation (HSCT).
作者信息
Rose Christian, Ernst Olivier, Hecquet Bernard, Maboudou Patrice, Renom Pascale, Noel Marie Pierre, Yakoub-Agha Ibrahim, Bauters Francis, Jouet Jean Pierre
机构信息
Service d'Hématologie, Groupe Hospitalier de l'Institut CatholiqueService of Hemotherapy and Hemostasis, Hospital Clínic, Barcelona, Spain.
出版信息
Haematologica. 2007 Jun;92(6):850-3. doi: 10.3324/haematol.11063.
We quantified and studied the impact of post transfusional iron overload alone in post allogeneic HSCT. Median number of RBCs was 18. Ferritin was 532 mg/L. Liver iron content (LIC) was 117 mmoles/gdw. Correlation RBCs and ferritin was (r=0.81); RBCs and LIC was (r=0.84). The high ferritin group differed from normal ferritin group in terms of RBCs transfused (p<10(-3)), ALT (p<0.009). But occurrence of liver dysfunction was not significant. Magnitude of iron overload correlates closely to the number of RBCs and is quantified by MRI. Impact on liver dysfunction is moderate in absence of co-morbidity.
我们对异基因造血干细胞移植后单纯输血后铁过载的影响进行了量化和研究。红细胞中位数为18。铁蛋白为532mg/L。肝脏铁含量（LIC）为117微摩尔/克干重。红细胞与铁蛋白的相关性为（r = 0.81）；红细胞与LIC的相关性为（r = 0.84）。高铁蛋白组与正常铁蛋白组在输注红细胞数量（p<10⁻³）、谷丙转氨酶（p<0.009）方面存在差异。但肝功能障碍的发生率无显著差异。铁过载的程度与红细胞数量密切相关，可通过磁共振成像（MRI）进行量化。在无合并症的情况下，对肝功能障碍的影响为中度。
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