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一种检测骨髓增生异常综合征主要表型异常的简单方法：慢性粒单核细胞白血病中CD56的表达

A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML.

作者信息

Lacronique-Gazaille Charlotte, Chaury Marie-Pierre, Le Guyader Alexandre, Faucher Jean-Luc, Bordessoule Dominique, Feuillard Jean

出版信息

Haematologica. 2007 Jun;92(6):859-60. doi: 10.3324/haematol.11118.

DOI:10.3324/haematol.11118
PMID:17550865
Abstract

Using a very simple flow cytometry protocol, we found that CD36 and CD117 on granulocytes and CD56 on monocytes were the major bone marrow phenotypic aberrations in patients with myelodysplasia, including CMML. CD56 on monocytes was associated with CMML. Importantly, phenotypic aberrations were lost on blood cells, except for CD56.

摘要

使用一种非常简单的流式细胞术方案，我们发现粒细胞上的CD36和CD117以及单核细胞上的CD56是骨髓增生异常综合征患者（包括慢性粒单核细胞白血病患者）主要的骨髓表型异常。单核细胞上的CD56与慢性粒单核细胞白血病相关。重要的是，除了CD56外，血细胞上的表型异常消失了。

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