Subirá Dolores, Font Patricia, Villalón Lucia, Serrano Cristina, Askari Elham, Góngora Elena, Castañón Susana, Gonzalo Raquel, Mata Raquel, Román Alejandro, Llamas Pilar
Department of Hematology, Fundación Jiménez Díaz, Madrid, Spain.
Transl Res. 2008 May;151(5):240-5. doi: 10.1016/j.trsl.2008.03.001. Epub 2008 Apr 7.
Chronic myelomonocytic leukemia (CMML) is a heterogeneous disease balanced between myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD). We used flow cytometry to describe and compare the immunophenotypic profile of 20 patients with CMML, 38 patients with MDS, and 20 patients with MPD. CMML and MDS only showed statistically significant differences (P<0.05) in CD56 monocyte expression. CMML and MPD showed significant differences in CD45 myeloid distribution, myeloid antigenic profile, CD56 and CD2 monocyte expression, and B-cell development. These data support the classic concept of CMML as part of MDS diseases and encourage including immunophenotyping among the studies to be performed in these diseases.
慢性粒单核细胞白血病（CMML）是一种在骨髓增生异常综合征（MDS）和骨髓增殖性疾病（MPD）之间平衡的异质性疾病。我们采用流式细胞术来描述和比较20例CMML患者、38例MDS患者和20例MPD患者的免疫表型特征。CMML和MDS仅在CD56单核细胞表达上显示出统计学显著差异（P<0.05）。CMML和MPD在CD45髓系分布、髓系抗原谱、CD56和CD2单核细胞表达以及B细胞发育方面存在显著差异。这些数据支持了CMML作为MDS疾病一部分的经典概念，并鼓励在这些疾病的研究中进行免疫表型分析。
