来自紫色粘细菌囊肿杆菌的首个羟基化阿扎利德：分离、结构解析及V-ATP酶抑制作用
The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus: isolation, structural elucidation and V-ATPase inhibition.
作者信息
Menche Dirk, Hassfeld Jorma, Steinmetz Heinrich, Huss Markus, Wieczorek Helmut, Sasse Florenz
机构信息
Helmholtz-Zentrum für Infektionsforschung GmbH, Medicinal Chemistry and Chemical Biology, Braunschweig, Germany.
出版信息
J Antibiot (Tokyo). 2007 May;60(5):328-31. doi: 10.1038/ja.2007.43.
The novel macrocyclic polyketide, 10-hydroxymethyl-archazolid-7-O-beta-D-glucopyranoside (archazolid D), was obtained from the myxobacterium Cystobacter violaceus. The structure of this first hydroxylated archazolid was determined by spectroscopic analysis, in particular by HMBC, HMQC, and ROESY NMR investigations, and by degradation. This novel metabolite was evaluated for growth inhibition of murine connective tissue cells and V-ATPase inhibition in comparison to other known archazolids.
新型大环聚酮化合物10-羟甲基-阿扎唑菌素-7-O-β-D-吡喃葡萄糖苷（阿扎唑菌素D）是从粘细菌紫色囊杆菌中获得的。通过光谱分析，特别是通过HMBC、HMQC和ROESY NMR研究以及降解，确定了这种首个羟基化阿扎唑菌素的结构。与其他已知的阿扎唑菌素相比，对这种新型代谢产物进行了小鼠结缔组织细胞生长抑制和V-ATP酶抑制的评估。
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