从粘细菌珊瑚状原囊菌中分离出的强效液泡型ATP酶抑制剂阿奇佐利德A和B的立体化学测定
Stereochemical determination of Archazolid A and B, highly potent vacuolar-type ATPase inhibitors from the Myxobacterium Archangium gephyra.
作者信息
Hassfeld Jorma, Farès Christophe, Steinmetz Heinrich, Carlomagno Teresa, Menche Dirk
机构信息
Gesellschaft für Biotechnologische Forschung mbH, Medizinische Chemie and Umweltmikrobiologie, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
出版信息
Org Lett. 2006 Oct 12;8(21):4751-4. doi: 10.1021/ol061831y.
[structure: see text] The relative and absolute stereochemistry of the structurally unique 24-membered myxobacterial macrolides archazolid A and B, highly potent vacuolar-type ATPase (V-ATPase) inhibitors in vitro and in vivo, was determined on the basis of a combination of extensive high-field NMR studies, including J-based configuration analysis, molecular modeling, and chemical methods.
[结构：见正文] 结构独特的24元粘细菌大环内酯类化合物阿奇唑立德A和B的相对和绝对立体化学，它们在体外和体内都是高效的液泡型ATP酶（V-ATP酶）抑制剂，是基于广泛的高场核磁共振研究（包括基于J的构型分析、分子建模和化学方法）的组合来确定的。
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