Ji Lv, Cao Xiu-Feng, Wang He-Ming, Li Yi-Sheng, Zhu Bin, Xiao Jian, Wang Dan
Affillted Nanjing First Hospital Oncology Center, Nanjing Medical University, Changle Road, Nanjing, Jiangsu Province, China.
World J Gastroenterol. 2007 May 14;13(18):2622-5. doi: 10.3748/wjg.v13.i18.2622.
To examine the association of beta-catenin with the clinicopathologic features and prognosis of esophageal squamous cell carcinoma (ESCC).
Beta-catenin mRNA expression level in 40 ESCC patients (28 males and 12 females, age range 38-82 years, median 60 years) was analyzed by real-time PCR. Beta-catenin mRNA expression levels in tumor cells were categorized as weaker (level 1) or equal to or stronger (level 2) than those in endothelial cells. We examined the correlation between the beta-catenin expression and the clinicopathological factors and prognosis of ESCC patients.
Level 2 beta-catenin expression was found in 29 patients. ESCC with level 2 expression had a higher rate of lymphnode metastasis (0.0776 +/- 0.0369 vs 0.3413 +/- 0.1803, P < 0.001) and deeper tumor invasion (0.0751 +/- 0.0356 vs 0.3667 +/- 0.1928, P < 0.001), and a poorer survival rate (P = 0.0024) than ESCC with level 1 expression.
Beta-catenin expression in ESCC is of great importance.
探讨β-连环蛋白与食管鳞状细胞癌（ESCC）临床病理特征及预后的相关性。
采用实时定量PCR分析40例ESCC患者（男28例，女12例，年龄38 - 82岁，中位年龄60岁）β-连环蛋白mRNA表达水平。肿瘤细胞中β-连环蛋白mRNA表达水平分为低于内皮细胞（1级）或等于或高于内皮细胞（2级）。我们研究了β-连环蛋白表达与ESCC患者临床病理因素及预后的相关性。
29例患者β-连环蛋白表达为2级。β-连环蛋白表达为2级的ESCC患者淋巴结转移率较高（0.0776±0.0369对0.3413±0.1803，P<0.001），肿瘤浸润深度更深（0.0751±0.0356对0.3667±0.1928，P<0.001），生存率低于β-连环蛋白表达为1级的ESCC患者（P = 0.0024）。
ESCC中β-连环蛋白的表达具有重要意义。
