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绝经后女性心血管系统的形态学和功能变化

Morphological and functional changes of cardiovascular system in postmenopausal women.

作者信息

Alessandri N, Piccioni M G, Isabelli V, Alessandri G, Di Matteo A, Padovani D, Rondoni G, Camardella B, Parlapiano C

机构信息

Dipartimento del Cuore e Grossi Vasi A. Reale U.O.S. Cardiology Polo Pontino, University of Rome La Sapienza, Rome, Italy.

出版信息

Eur Rev Med Pharmacol Sci. 2007 Mar-Apr;11(2):107-17.

PMID:17552140
Abstract

BACKGROUND

The incidence of cardiovascular events in reproductive age women is 3 times lower than in men, whereas this ratio noticeably changes on menopausal beginning. Postmenopausal women are more exposed to the effects of risk factors, which are present in a noticeably different entity in physiological or surgical menopause; and in the latter whether on substitutive hormonal treatment or not.

METHODS

This study, carried out in Rome and Latina, has involved 743 postmenopausal women, of whom 545 with physiological menopause and 198 with iatrogenic menopause.

RESULTS

The average blood pressure value as well as the incidence of hypertension, hypercholesterolemia, diabetes mellitus, obesity and smoking have a significantly different trend in physiological versus iatrogenic postmenopausal women; and in the latter whether on substitutive hormonal treatment or not.

CONCLUSIONS

Studying life-style and evaluating risk factors in postmenopausal women, and giving an up-to-date view about the prevalence oh health conditions at risk, will allow us to promote both primary and secondary prevention actions.

摘要

背景

育龄期女性心血管事件的发生率比男性低3倍,而在绝经开始时这一比例会显著变化。绝经后女性更容易受到危险因素的影响,这些危险因素在生理性或手术绝经中的表现明显不同;对于手术绝经后的女性,无论是否接受替代激素治疗都是如此。

方法

这项在罗马和拉蒂纳进行的研究纳入了743名绝经后女性,其中545名生理性绝经,198名医源性绝经。

结果

生理性绝经与医源性绝经的女性在平均血压值以及高血压、高胆固醇血症、糖尿病、肥胖和吸烟的发生率方面有显著不同的趋势;对于医源性绝经的女性,无论是否接受替代激素治疗都是如此。

结论

研究绝经后女性的生活方式并评估危险因素,以及提供有关高危健康状况患病率的最新观点,将使我们能够促进一级和二级预防行动。

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