Delaney J A Chris, Dial Sandra, Barkun Alan, Suissa Samy
McGill University Health Center, Montreal, Quebec, Canada.
Emerg Infect Dis. 2007 May;13(5):761-3. doi: 10.3201/eid1305.061124.
In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months.
在一项基于人群的社区获得性艰难梭菌相关疾病(CDAD)病例对照研究中,我们将1233例病例与12330例对照进行匹配。使用任何抗菌药物会使CDAD风险增加3倍,使用氟喹诺酮类药物会使其风险增加6倍。抗菌药物的既往使用情况在6个月后并不影响CDAD风险。